Option 1
London + surrounding -> eurostar to Brussels -> Bruges -> Amsterdam or any other places in Holland -> Paris -> Dijon or Burgundy Region for vineyard -> Berne (Switzerland) -> Lucerne/Zurich + up Titlis -> Lake Lugano/Como -> Milan -> Verona -> Venice -> Florence -> Pisa - Rome
Option 2
London + surrounding -> eurostar to Brussels -> Bruges -> Amsterdam or any other places in Holland -> Paris -> Loire Valley -> High speed train to Avignon -> Marseille -> Nice/Cannes/Monte Carlo -> Chamonix + Mont Blanc -> Geneva -> Montreux -> Laussane -> Interlaken + up Jungfrau -> Lucerne/Zurich + up Titlis -> Lake Lugano/Como -> Milan -> Verona -> Venice -> Florence -> Pisa - Rome
Option 3
London + surrounding -> eurostar to Brussels -> Bruges -> Amsterdam or any other places in Holland -> Paris -> Loire Valley -> High speed train to Avignon -> Marseille -> Nice/Cannes/Monte Carlo -> Chamonix + Mont Blanc -> Geneva -> Montreux -> Laussane -> Zermatt -> Glacier Express to St Moritz --> train to Venice --> Verona -> Milan -> Florence -> Piza -> Rome